Hs03791953_cn

• Gene Symbol: SIRT3
• Assay Reference Genome Location: Chr.11:223696 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 23410
• Gene Name: sirtuin 3
• Gene Aliases: SIR2L3
• Location: Chr.11:215030-236950 on Build GRCh38
• Assay Gene Location: Within Intron 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIRT3	NM_001017524.2			NP_001017524.1
	NM_012239.5			NP_036371.1
	XM_005252835.1			XP_005252892.1
	XM_011519956.1			XP_011518258.1
	XM_011519957.1			XP_011518259.1
	XM_017017428.1			XP_016872917.1
	XM_017017429.1			XP_016872918.1
	XM_017017430.1			XP_016872919.1
	XM_017017431.1			XP_016872920.1
	AF083108.2			AAD40851.1
	AK074992.1	3	472
	AK298572.1
	AK299009.1
	AK299438.1
	AK301558.1
	AK301979.1
	AK316175.1
	AL137276.1			CAB70674.1
	AL535769.3
	BC001042.2			AAH01042.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32593	Chr.11:218394 - 285937 on Build GRCh38	Loss	NLRP6 SIRT3 PSMD13
esv3625061	Chr.11:195766 - 233956 on Build GRCh38	Gain	RIC8A BET1L MIR6743 SIRT3 ODF3
esv3625060	Chr.11:194412 - 252166 on Build GRCh38	Gain	SCGB1C1 RIC8A BET1L MIR6743 SIRT3 PSMD13 ODF3
nsv469921	Chr.11:219089 - 276012 on Build GRCh38	Gain	SIRT3 PSMD13
nsv552765	Chr.11:199256 - 320836 on Build GRCh38	Gain	RIC8A NLRP6 IFITM2 BET1L IFITM1 PGGHG MIR6743 IFITM5 SIRT3 IFITM3 PSMD13 ODF3
dgv1011n100	Chr.11:198510 - 275185 on Build GRCh38	Gain	RIC8A BET1L MIR6743 SIRT3 PSMD13 ODF3
esv2413108	Chr.11:223721 - 224144 on Build GRCh38	Deletion	SIRT3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
protein deacetylation
mitochondrion organization
aerobic respiration
peptidyl-lysine deacetylation
histone H3 deacetylation
negative regulation of peptidyl-lysine acetylation

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NAD+ binding