Hs03791949_cn

• Gene Symbol: SYTL2
• Assay Reference Genome Location: Chr.11:85702672 on build GRCh38
• Cytoband: 11q14.1

Target Gene Details

• Entrez Gene ID: 54843
• Gene Name: synaptotagmin like 2
• Gene Aliases: CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A
• Location: Chr.11:85694221-85811182 on Build GRCh38
• Assay Gene Location: Within Intron 17

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SYTL2	NM_001162951.2			NP_001156423.1
	NM_001162952.2			NP_001156424.1
	NM_001162953.2			NP_001156425.1
	NM_001289608.1			NP_001276537.1
	NM_001289609.1			NP_001276538.1
	NM_001289610.1			NP_001276539.1
	NM_032943.4			NP_116561.1
	NM_206929.3			NP_996812.1
	NM_206930.3			NP_996813.1
	XM_005274057.1			XP_005274114.1
	XM_005274060.1			XP_005274117.1
	XM_005274061.1			XP_005274118.1
	XM_005274062.2			XP_005274119.1
	XM_005274063.1			XP_005274120.1
	XM_005274066.1			XP_005274123.1
	XM_005274067.4			XP_005274124.1
	XM_011545105.1			XP_011543407.1
	XM_011545106.1			XP_011543408.1
	XM_011545107.2			XP_011543409.1
	XM_011545108.1			XP_011543410.1
	XM_011545109.2			XP_011543411.1
	XM_011545110.1			XP_011543412.1
	XM_011545114.2			XP_011543416.1
	XM_011545115.1			XP_011543417.1
	XM_011545116.2			XP_011543418.1
	XM_017017933.1			XP_016873422.1
	XM_017017934.1			XP_016873423.1
	XM_017017935.1			XP_016873424.1
	XM_017017936.1			XP_016873425.1
	XM_017017937.1			XP_016873426.1
	XM_017017938.1			XP_016873427.1
	XM_017017939.1			XP_016873428.1
	XM_017017940.1			XP_016873429.1
	AB046817.1			BAB13423.1
	AK024872.1			BAB15030.1
	AK074737.1			BAC11170.1
	AK092121.1
	AK124754.1			BAC85937.1
	AK127504.1			BAC87010.1
	AK131365.1			BAD18516.1
	AK222707.1
	AK222710.1
	AK296224.1
	AK296740.1
	AK298604.1
	AL834422.1			CAD39083.1
	AY386362.1			AAR25619.1
	BC015540.2
	BC110315.1			AAI10316.1
	BC136450.1
	BC144114.1
	BC144115.1
	BX647671.1
	BX648068.1
	EU035829.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv832222	Chr.11:85694669 - 85892938 on Build GRCh38	Gain	SYTL2 CCDC83
nsv468768	Chr.11:85684137 - 85725309 on Build GRCh38	Loss	CCDC89 SYTL2
esv2759845	Chr.11:85469436 - 85892945 on Build GRCh38	Gain+Loss	TMEM126A CCDC89 TMEM126B DLG2 SYTL2 CREBZF CCDC83

More Information

Additional Information:

For this assay, SNP(s) [rs79422696] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

intracellular protein transport
exocytosis
vesicle docking involved in exocytosis
vesicle fusion
negative regulation of phosphatase activity
vesicle-mediated transport
regulation of calcium ion-dependent exocytosis
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of mucus secretion
protein localization to plasma membrane

Function(s)

phosphatidylserine binding
calcium ion binding
protein binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
Rab GTPase binding
phosphatase binding
syntaxin binding
clathrin binding
neurexin family protein binding