Hs02922012_cn

• Gene Symbol: HEY2
• Assay Reference Genome Location: Chr.6:125761057 on build GRCh38
• Cytoband: 6q22.31

Target Gene Details

• Entrez Gene ID: 23493
• Gene Name: hes related family bHLH transcription factor with YRPW motif 2
• Gene Aliases: CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32
• Location: Chr.6:125747592-125762243 on Build GRCh38
• Assay Gene Location: Within Exon 7

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HEY2	NM_012259.2	5	2460	NP_036391.1
	XM_017010627.1	5	3844	XP_016866116.1
	XM_017010628.1	6	3542	XP_016866117.1
	XM_017010629.1	5	2321	XP_016866118.1
	AJ249545.1	5	2319	CAB56839.1

More Information

Additional Information:

For this assay, SNP(s) [rs75759893] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, non-DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
muscular septum morphogenesis
outflow tract morphogenesis
pulmonary valve morphogenesis
tricuspid valve morphogenesis
tricuspid valve formation
endocardial cushion to mesenchymal transition involved in heart valve formation
cardiac ventricle morphogenesis
cardiac left ventricle morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
transcription, DNA-templated
Notch signaling pathway
anterior/posterior axis specification
positive regulation of heart rate
negative regulation of transcription by transcription factor localization
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
mesenchymal cell development
cardiac muscle hypertrophy in response to stress
ascending aorta morphogenesis
dorsal aorta morphogenesis
umbilical cord morphogenesis
cell fate commitment
regulation of auditory receptor cell differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cardiac epithelial to mesenchymal transition
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
atrial septum morphogenesis
negative regulation of transcription initiation from RNA polymerase II promoter
labyrinthine layer blood vessel development
arterial endothelial cell differentiation
cardiac vascular smooth muscle cell development
coronary vasculature morphogenesis
pulmonary artery morphogenesis
Notch signaling involved in heart development
protein-DNA complex assembly
cochlea development
vascular smooth muscle cell development
negative regulation of transcription regulatory region DNA binding
negative regulation of cardiac vascular smooth muscle cell differentiation
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
regulation of vasculogenesis

Function(s)

transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, protein binding
RNA polymerase II activating transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
microsatellite binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
protein heterodimerization activity