Hs02104724_cn

• Gene Symbol: MAP4K2
• Assay Reference Genome Location: Chr.11:64796647 on build GRCh38
• Cytoband: 11q13.1

Target Gene Details

• Entrez Gene ID: 5871
• Gene Name: mitogen-activated protein kinase kinase kinase kinase 2
• Gene Aliases: BL44, GCK, RAB8IP
• Location: Chr.11:64786914-64803254 on Build GRCh38
• Assay Gene Location: Overlaps Intron 22 - Exon 22

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAP4K2	NM_001307990.1			NP_001294919.1
	NM_004579.4			NP_004570.2
	XM_011545203.2			XP_011543505.1
	XM_011545204.2			XP_011543506.1
	XM_017018093.1			XP_016873582.1
	XM_017018094.1			XP_016873583.1
	XM_017018095.1			XP_016873584.1
	XM_017018096.1			XP_016873585.1
	AK298383.1
	BC047865.1			AAH47865.1
	U07349.1			AAA20968.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv528506	Chr.11:64577976 - 64933558 on Build GRCh38	Loss	SF1 MIR192 RASGRP2 MIR194-2 MAP4K2 MIR194-2HG MIR6749 CDC42BPG SLC22A12 ATG2A EHD1 MIR6750 PPP2R5B NRXN2 PYGM MEN1
dgv72n21	Chr.11:64778919 - 64817515 on Build GRCh38	Loss	SF1 MAP4K2 MEN1
nsv469962	Chr.11:64759608 - 64854101 on Build GRCh38	Loss	SF1 EHD1 MAP4K2 PYGM MEN1 CDC42BPG
dgv1968n54	Chr.11:64793728 - 64808033 on Build GRCh38	Loss	MAP4K2 MEN1
dgv1965n54	Chr.11:64566642 - 64806117 on Build GRCh38	Loss	SLC22A12 SF1 NRXN2 RASGRP2 MAP4K2 PYGM MEN1 SLC22A11
nsv951013	Chr.11:64777329 - 64847128 on Build GRCh38	Deletion	SF1 MAP4K2 MEN1 CDC42BPG
dgv153n27	Chr.11:64709578 - 64817487 on Build GRCh38	Loss	SF1 NRXN2 RASGRP2 MAP4K2 PYGM MEN1
nsv832189	Chr.11:64719711 - 64852727 on Build GRCh38	Loss	SF1 EHD1 NRXN2 RASGRP2 MAP4K2 PYGM MEN1 CDC42BPG

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

activation of MAPKKK activity
protein phosphorylation
vesicle targeting
immune response
JNK cascade
activation of JUN kinase activity
intracellular signal transduction
innate immune response
positive regulation of JNK cascade

Function(s)

protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
MAP kinase kinase kinase kinase activity
mitogen-activated protein kinase kinase kinase binding