Hs01984630_cn

• Gene Symbol: PTPN5
• Assay Reference Genome Location: Chr.11:18728124 on build GRCh38
• Cytoband: 11p15.1

Target Gene Details

• Entrez Gene ID: 84867
• Gene Name: protein tyrosine phosphatase, non-receptor type 5
• Gene Aliases: PTPSTEP, STEP, STEP61
• Location: Chr.11:18727928-18792721 on Build GRCh38
• Assay Gene Location: Within Exon 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTPN5	NM_001039970.1	15	2843	NP_001035059.1
	NM_001278236.1	15	3677	NP_001265165.1
	NM_001278238.1	14	2806	NP_001265167.1
	NM_001278239.1	14	2710	NP_001265168.1
	NM_006906.1	15	2939	NP_008837.1
	NM_032781.3	15	2894	NP_116170.3
	XM_011520411.2	15	2925	XP_011518713.1
	XM_017018434.1	14	2717	XP_016873923.1
	XM_017018435.1	14	2687	XP_016873924.1
	XM_017018436.1	13	2623	XP_016873925.1
	XM_017018437.1	14	2641	XP_016873926.1
	XM_017018438.1	12	2402	XP_016873927.1
	XM_017018439.1	13	2528	XP_016873928.1
	XM_017018440.1	14	2764	XP_016873929.1
	AK027333.1	1	880
	AK055450.1	3	2105
	AK090923.1			BAC03548.1
	AK127312.1	15	3677
	AL832541.1	15	2938	CAD38632.2
	BC039897.1	14	2602	AAH39897.1
	BC046435.1	5	1418	AAH46435.1
	BC064807.1	15	2703	AAH64807.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1047371	Chr.11:18709926 - 18741490 on Build GRCh38	Gain	PTPN5 IGSF22
nsv553633	Chr.11:18290154 - 19036904 on Build GRCh38	Gain	SPTY2D1-AS1 HPS5 PTPN5 LDHA TMEM86A MRGPRX1 TSG101 LDHC LDHAL6A UEVLD SPTY2D1 IGSF22 GTF2H1 MIR3159
nsv525192	Chr.11:18701244 - 18771813 on Build GRCh38	Loss	PTPN5 TMEM86A IGSF22
nsv525452	Chr.11:18714400 - 18780956 on Build GRCh38	Gain	PTPN5 IGSF22

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
response to amphetamine
positive regulation of receptor internalization
protein dephosphorylation
positive regulation of neuron projection development
positive regulation of protein import into nucleus, translocation
peptidyl-tyrosine dephosphorylation
exploration behavior
response to immobilization stress
response to drug
negative regulation of MAP kinase activity
positive regulation of long-term synaptic potentiation
positive regulation of neuron death
response to acetylsalicylate
positive regulation of protein targeting to mitochondrion
positive regulation of response to drug

Function(s)

phosphotyrosine binding
protein tyrosine phosphatase activity
protein binding
glutamate receptor binding
mitogen-activated protein kinase binding