Hs01860414_cn

• Gene Symbol: ATF4
• Assay Reference Genome Location: Chr.22:39520579 on build GRCh38
• Cytoband: 22q13.1

Target Gene Details

• Entrez Gene ID: 468
• Gene Name: activating transcription factor 4
• Gene Aliases: CREB-2, CREB2, TAXREB67, TXREB
• Location: Chr.22:39519709-39522686 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ATF4	NM_001675.4			NP_001666.2
	NM_182810.2			NP_877962.1
	XM_017028807.1	2	495	XP_016884296.1
	AK057751.1
	AK296028.1
	BC008090.1			AAH08090.1
	BC011994.1			AAH11994.1
	BC016855.2			AAH16855.1
	BC022088.2			AAH22088.1
	BC024775.1			AAH24775.1
	BC044895.1			AAH44895.1
	BC073754.1			AAH73754.1
	D90209.1			BAA14234.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834199	Chr.22:39324389 - 39531343 on Build GRCh38	Loss	SYNGR1 ATF4 MIEF1 MGAT3-AS1 RPS19BP1 LOC100506472 MGAT3 TAB1
nsv3629	Chr.22:39504067 - 39534583 on Build GRCh38	Insertion	ATF4 MIEF1 RPS19BP1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

gluconeogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular amino acid metabolic process
gamma-aminobutyric acid signaling pathway
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of translational initiation in response to stress
circadian regulation of gene expression
cellular response to amino acid starvation
cellular response to UV
response to endoplasmic reticulum stress
positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
mRNA transcription from RNA polymerase II promoter
positive regulation of apoptotic process
negative regulation of potassium ion transport
positive regulation of neuron apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of oxidative stress-induced neuron death
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
response to manganese-induced endoplasmic reticulum stress

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein C-terminus binding
leucine zipper domain binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity