Hs01782754_cn

• Gene Symbol: SIRT3
• Assay Reference Genome Location: Chr.11:233361 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 23410
• Gene Name: sirtuin 3
• Gene Aliases: SIR2L3
• Location: Chr.11:215030-236950 on Build GRCh38
• Assay Gene Location: Overlaps Intron 4 - Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIRT3	NM_001017524.2			NP_001017524.1
	NM_012239.5			NP_036371.1
	XM_005252835.1			XP_005252892.1
	XM_011519956.1			XP_011518258.1
	XM_011519957.1			XP_011518259.1
	XM_017017428.1			XP_016872917.1
	XM_017017429.1			XP_016872918.1
	XM_017017430.1			XP_016872919.1
	XM_017017431.1			XP_016872920.1
	AF083108.2			AAD40851.1
	AK074992.1
	AK298572.1
	AK299009.1
	AK299438.1
	AK301558.1
	AK301979.1
	AK308681.1
	AK316175.1
	AL535769.3
	BC001042.2			AAH01042.1
	BI755839.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32593	Chr.11:218394 - 285937 on Build GRCh38	Loss	PSMD13 SIRT3 NLRP6
esv3625061	Chr.11:195766 - 233956 on Build GRCh38	Gain	BET1L SIRT3 ODF3 RIC8A MIR6743
esv3625060	Chr.11:194412 - 252166 on Build GRCh38	Gain	BET1L PSMD13 SIRT3 SCGB1C1 ODF3 RIC8A MIR6743
nsv469921	Chr.11:219089 - 276012 on Build GRCh38	Gain	PSMD13 SIRT3
nsv552765	Chr.11:199256 - 320836 on Build GRCh38	Gain	BET1L PSMD13 SIRT3 NLRP6 ODF3 RIC8A IFITM5 MIR6743 PGGHG IFITM3 IFITM1 IFITM2
nsv7632	Chr.11:224495 - 256679 on Build GRCh38	Insertion	PSMD13 SIRT3
dgv1011n100	Chr.11:198510 - 275185 on Build GRCh38	Gain	BET1L PSMD13 SIRT3 ODF3 RIC8A MIR6743

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
protein deacetylation
mitochondrion organization
aerobic respiration
peptidyl-lysine deacetylation
histone H3 deacetylation
negative regulation of peptidyl-lysine acetylation

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
zinc ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
NAD+ binding