Hs00977216_cn

• Gene Symbol: TIGIT
• Assay Reference Genome Location: Chr.3:114307900 on build GRCh38
• Cytoband: 3q13.31

Target Gene Details

• Entrez Gene ID: 201633
• Gene Name: T-cell immunoreceptor with Ig and ITIM domains
• Gene Aliases: VSIG9, VSTM3, WUCAM
• Location: Chr.3:114293986-114310288 on Build GRCh38
• Assay Gene Location: Overlaps Intron 4 - Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TIGIT	NM_173799.3			NP_776160.2
	XM_011512538.1			XP_011510840.1
	XM_017005865.1			XP_016861354.1
	AK097192.1			BAC04973.1
	AL833175.1			CAI46183.1
	BC101288.1			AAI01289.1
	BC101289.1			AAI01290.1
	BC101290.1			AAI01291.1
	BC101291.1			AAI01292.1
	BX640915.1			CAE45956.1
	EU675310.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3597455	Chr.3:114305165 - 114307900 on Build GRCh38	Loss	TIGIT
nsv822223	Chr.3:114305155 - 114308001 on Build GRCh38	Loss	TIGIT

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell recognition
negative regulation of interleukin-12 production
positive regulation of interleukin-10 production
negative regulation of T cell activation

Function(s)

receptor activity
receptor binding
protein binding
protein homodimerization activity
cell adhesion molecule binding