Hs00326129_cn

• Gene Symbol: PTPN5
• Assay Reference Genome Location: Chr.11:18728664 on build GRCh38
• Cytoband: 11p15.1

Target Gene Details

• Entrez Gene ID: 84867
• Gene Name: protein tyrosine phosphatase, non-receptor type 5
• Gene Aliases: PTPSTEP, STEP, STEP61
• Location: Chr.11:18727928-18792721 on Build GRCh38
• Assay Gene Location: Within Exon 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTPN5	NM_001039970.1	15	2303	NP_001035059.1
	NM_001278236.1	15	3137	NP_001265165.1
	NM_001278238.1	14	2266	NP_001265167.1
	NM_001278239.1	14	2170	NP_001265168.1
	NM_006906.1	15	2399	NP_008837.1
	NM_032781.3	15	2354	NP_116170.3
	XM_011520411.2	15	2385	XP_011518713.1
	XM_017018434.1	14	2177	XP_016873923.1
	XM_017018435.1	14	2147	XP_016873924.1
	XM_017018436.1	13	2083	XP_016873925.1
	XM_017018437.1	14	2101	XP_016873926.1
	XM_017018438.1	12	1862	XP_016873927.1
	XM_017018439.1	13	1988	XP_016873928.1
	XM_017018440.1	14	2224	XP_016873929.1
	AK027333.1	1	340
	AK055450.1	3	1565
	AK090923.1	15	2263	BAC03548.1
	AK127312.1	15	3137
	AK294374.1	14	2006
	AK294673.1	14	1967
	AK295604.1	14	2127
	AL832541.1	15	2398	CAD38632.2
	BC039897.1	14	2062	AAH39897.1
	BC046435.1	5	878	AAH46435.1
	BC064807.1	15	2163	AAH64807.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1047371	Chr.11:18709926 - 18741490 on Build GRCh38	Gain	IGSF22 PTPN5
nsv553633	Chr.11:18290154 - 19036904 on Build GRCh38	Gain	LDHA SPTY2D1 LDHC PTPN5 MRGPRX1 SPTY2D1-AS1 IGSF22 MIR3159 UEVLD TMEM86A TSG101 GTF2H1 LDHAL6A HPS5
nsv525192	Chr.11:18701244 - 18771813 on Build GRCh38	Loss	IGSF22 TMEM86A PTPN5
nsv525452	Chr.11:18714400 - 18780956 on Build GRCh38	Gain	IGSF22 PTPN5

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
response to amphetamine
positive regulation of receptor internalization
protein dephosphorylation
positive regulation of neuron projection development
positive regulation of protein import into nucleus, translocation
peptidyl-tyrosine dephosphorylation
exploration behavior
response to immobilization stress
response to drug
negative regulation of MAP kinase activity
positive regulation of long-term synaptic potentiation
positive regulation of neuron death
response to acetylsalicylate
positive regulation of protein targeting to mitochondrion
positive regulation of response to drug

Function(s)

phosphotyrosine binding
protein tyrosine phosphatase activity
protein binding
glutamate receptor binding
mitogen-activated protein kinase binding