Hs00113634_cn

• Gene Symbol: AKT2
• Assay Reference Genome Location: Chr.19:40233964 on build GRCh38
• Cytoband: 19q13.2

Target Gene Details

• Entrez Gene ID: 208
• Gene Name: AKT serine/threonine kinase 2
• Gene Aliases: HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
• Location: Chr.19:40230317-40285531 on Build GRCh38
• Assay Gene Location: Overlaps Intron 21 - Exon 22

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
AKT2	NM_001243027.2			NP_001229956.1
	NM_001243028.2			NP_001229957.1
	NM_001626.5			NP_001617.1
	XM_011526614.1			XP_011524916.1
	XM_011526615.1			XP_011524917.1
	XM_011526616.1			XP_011524918.1
	XM_011526618.1			XP_011524920.1
	XM_011526619.1			XP_011524921.1
	XM_011526620.1			XP_011524922.1
	XM_017026470.1			XP_016881959.1
	XM_017026471.1			XP_016881960.1
	AK054771.1
	AK055779.1
	AK122839.1
	AK294453.1
	AK308006.1
	AK314619.1
	BC022779.1			AAH22779.1
	BC063421.1			AAH63421.1
	BC120994.1
	BC120995.1
	KU159425.1
	M77198.1			AAA36585.1
	M95936.1			AAA58364.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1062755	Chr.19:40231556 - 40252328 on Build GRCh38	Loss	AKT2
esv3644345	Chr.19:40203124 - 40288712 on Build GRCh38	Gain	CNTD2 MIR641 TTC9B AKT2 MAP3K10
esv3644344	Chr.19:40191059 - 40328585 on Build GRCh38	Gain	CNTD2 MIR641 C19orf47 TTC9B AKT2 MAP3K10
esv2758761	Chr.19:40106513 - 40333613 on Build GRCh38	Gain	CNTD2 MIR641 C19orf47 TTC9B AKT2 MAP3K10

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, protein modifying enzyme

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
glycogen biosynthetic process
glucose metabolic process
regulation of translation
cellular protein modification process
apoptotic process
response to osmotic stress
signal transduction
insulin receptor signaling pathway
carbohydrate transport
positive regulation of signal transduction
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
response to muscle activity
peptidyl-serine phosphorylation
regulation of cell migration
positive regulation of cell migration
positive regulation of vesicle fusion
response to nutrient levels
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
cellular response to insulin stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of positive chemotaxis
mammary gland epithelial cell differentiation
intracellular protein transmembrane transport
regulation of cell cycle arrest
cellular response to organic cyclic compound
protein localization to plasma membrane
positive regulation of protein targeting to membrane
activation of GTPase activity
positive regulation of cell motility
positive regulation of glucose import in response to insulin stimulus

Function(s)

protein serine/threonine kinase activity
protein kinase C binding
protein binding
ATP binding