Invitrogen
Catalog # PA5-49742
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:100 |
Western Blot (WB) | 1:500-1:3,000 |
Species reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthesized peptide derived from human GluR8. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 50% glycerol |
Contains | 0.02% sodium azide |
Storage conditions | -20°C |
RRID | AB_2635195 |
The antibody detects endogenous levels of total mGluR8 protein.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ41058; G protein coupled receptor, family C, group 1, member H; G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; glutamate receptor; glutamate receptor, metabotropic 8; M mGlu8; Metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; MGC126724; mGluR8
Gene Aliases: A230002O04; GLUR8; GPRC1H; GRM8; mGlu8; mGlur; MGLUR8; mGluR8b
UniProt ID: (Human) O00222, (Rat) P70579, (Mouse) P47743
Entrez Gene ID: (Human) 2918, (Rat) 60590, (Mouse) 14823
Molecular Function:
G-protein coupled receptor
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