Invitrogen
Catalog # OPA1-04060
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (IHC) | 1:500 |
Western Blot (WB) | 1:1,000 |
Species reactivity | Mouse, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to the C-terminal region of rat GRM1 conjugated to KLH |
Conjugate | Unconjugated |
Form | Liquid |
Purification | Affinity chromatography |
Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
Contains | no preservative |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_2115764 |
This antibody is specific to MGluR1a and does not cross-react with other splice variants.
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor; GRM1A; Metabotropic glutamate receptor 1; mGluR1; mGluR1a
Gene Aliases: 4930455H15Rik; ENSMUSG00000075319; Gm10828; Gprc1a; Grm1; Mglur1; nmf373; rcw; wobl
UniProt ID: (Mouse) P97772, (Rat) P23385
Entrez Gene ID: (Mouse) 14816, (Rat) 24414
Molecular Function:
G-protein coupled receptor
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