Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View details.
Catalog # AHB0261
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
ELISA (ELISA) | Assay-dependent |
Immunohistochemistry (Paraffin) (IHC (P)) | 1:10-1:50 |
Western Blot (WB) | 1 µg/mL |
Immunocytochemistry (ICC/IF) | 1 µg/mL |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 12 publications below |
Immunohistochemistry (IHC) | See 10 publications below |
Immunoprecipitation (IP) | See 1 publications below |
Immunohistochemistry (Paraffin) (IHC (P)) | See 1 publications below |
Immunocytochemistry (ICC/IF) | See 2 publications below |
Dot blot (DB) | See 1 publications below |
ELISA (ELISA) | See 1 publications below |
Immunohistochemistry - Free Floating (IHC (Free)) | See 1 publications below |
Species reactivity | Human |
Published species | Avian, Guinea pig, Human, Mouse, Rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Clone | Syn 211 |
Immunogen | Recombinant human alpha-synuclein. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 0.5 mg/mL |
Purification | Protein A/G |
Storage buffer | PBS, pH 7.2, with 0.1% BSA |
Contains | 0.1% sodium azide |
Storage conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
RRID | AB_2536241 |
A suggested positive control for this product is SHSY-5Y cells. It will not cross-react with mouse or rat.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha synuclein; Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
Gene Aliases: NACP; PARK1; PARK4; PD1; SNCA
UniProt ID: (Human) P37840
Entrez Gene ID: (Human) 6622
Molecular Function:
membrane trafficking regulatory protein
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