Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View details.
Catalog # MA1-24654
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Western Blot (WB) | 1:25-1:50 |
Immunocytochemistry (ICC/IF) | 1:50 |
PUBLISHED APPLICATIONS | |
---|---|
Immunohistochemistry (IHC) | See 8 publications below |
Immunocytochemistry (ICC/IF) | See 2 publications below |
Species reactivity | Human, Mouse, Rat |
Published species | Human, Mouse, Rat |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Clone | 185 |
Immunogen | Recombinant protein corresponding to the C-terminal portion of mouse Tyrosine Hydroxylase. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 0.24 mg/mL |
Storage buffer | tissue culture supernatant |
Contains | 15mM sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_795666 |
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase
Gene Aliases: DYT14; DYT5b; TH; The; TYH
UniProt ID: (Human) P07101, (Mouse) P24529, (Rat) P04177
Entrez Gene ID: (Human) 7054, (Mouse) 21823, (Rat) 25085
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