Invitrogen
Catalog # MA1-80015
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Flow Cytometry (Flow) | Assay-dependent |
Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
Immunoprecipitation (IP) | Assay-dependent |
Western Blot (WB) | 1-2 µg/mL |
Species reactivity | Mouse |
Host / Isotype | Rat / IgG2a |
Class | Monoclonal |
Type | Antibody |
Clone | YTA74.4 |
Immunogen | Murine Concanavilin A activated spleen cells. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Protein G |
Storage buffer | PBS |
Contains | 0.09% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_929355 |
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Rat anti Mouse CD71 antibody, clone YTA74.4 recognizes the mouse Transferrin receptor protein 1 also known as CD71 or TfR1.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD antigen CD71; CD71; mammary tumor virus receptor 1; TR; Transferrin receptor protein 1
Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; p90; TFR; TFR1; Tfrc; TR; Trfr
UniProt ID: (Mouse) Q62351
Entrez Gene ID: (Mouse) 22042
Molecular Function:
metalloprotease
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