Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View details.
Catalog # PA5-49688
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (IHC) | 1:100-1:500 |
Western Blot (WB) | 1:500-1:1,000 |
PUBLISHED APPLICATIONS | |
---|---|
Immunohistochemistry (IHC) | See 2 publications below |
Immunocytochemistry (ICC/IF) | See 1 publications below |
Species reactivity | Human, Mouse, Rat |
Published species | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide sequence around aa.18~22(S-N-S-E-E) derived from Human Twist1 |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Affinity chromatography |
Storage buffer | PBS, pH 7.4, with 50% glycerol |
Contains | 0.02% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2635141 |
The antibody detects endogenous levels of total TWIST1 protein.
TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-HLH DNA binding protein; bHLHa38; charlie chaplin; Class A basic helix-loop-helix protein 38; H-twist; M-twist; p ACS3; Pluridigite; polydactyly EMS; Ska<sup>m10Jus</sup>; twist basic helix-loop-helix transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist-related protein 1
Gene Aliases: AA960487; ACS3; BHLHA38; BPES2; BPES3; CRS; CRS1; CSO; M-Twist; Pde; pdt; SCS; Ska10; Ska<m10Jus>; TWIST; TWIST1
UniProt ID: (Human) Q15672, (Mouse) P26687
Entrez Gene ID: (Human) 7291, (Mouse) 22160, (Rat) 85489
Molecular Function: basic helix-loop-helix transcription factor
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