Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View details.
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (IHC) | 1:300 - 1:3000 |
Western Blot (WB) | 1:300 - 1:3000 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | A synthetic peptide from rat Sortilin conjugated to blue carrier protein was used as the antigen. |
Conjugate | Unconjugated |
Form | Lyophilized |
Concentration | Conc. Not Determined |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
RRID | AB_1960718 |
Reconstitute with 100 µL of distilled water.
The peptide shares 95% identity with mouse's.
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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