Catalog # PA3-207
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Western Blot (WB) | 1:5,000 |
Immunocytochemistry (ICC/IF) | 1:5,000 |
PUBLISHED APPLICATIONS | |
---|---|
Immunohistochemistry (IHC) | See 1 publications below |
Species reactivity | Mouse, Rat |
Published species | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3 |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | Conc. Not Determined |
Storage buffer | whole serum |
Contains | 0.02% sodium azide |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_10981488 |
PA3-207 detects SSTR3 in rat and mouse samples.
PA3-207 has successfully been used in Western blot, immunofluorescence, immunocytochemical, and immunohistochemical (paraffin) procedures.
The PA3-207 immunogen is a synthetic peptide corresponding to the C-terminal amino acids T(417)AGDKASTLSHL(428) of SSTR3
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: somatostatin receptor; somatostatin receptor 28; somatostatin receptor subtype 3; Somatostatin receptor type 3; SS-3-R; SS3-R; SS3R; SSR-28
Gene Aliases: Smstr-3; Smstr28; Smstr3; sst3; SSTR; Sstr3
UniProt ID: (Mouse) P30935, (Rat) P30936
Entrez Gene ID: (Mouse) 20607, (Rat) 171044
Molecular Function:
G-protein coupled receptor
transmembrane signal receptor
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