Catalog # PA1-86737
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (IHC) | Assay-dependent |
Western Blot (WB) | 0.5-2 µg/mL |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 3 publications below |
Species reactivity | Human, Mouse |
Published species | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | 13 amino acid peptide sequence near the centre of human Slug |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Affinity chromatography |
Storage buffer | PBS |
Contains | 0.02% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2302174 |
In Western blot, this antibody detects a band at ~30kDa in 293 cell lysate.
Rabbit anti Slug antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-beta.
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC10182; Neural crest transcription factor Slug; Protein snail homolog 2; slug (chicken homolog), zinc finger protein; slug, chicken homolog; snail family zinc finger 2; snail homolog 2; Zinc finger protein SNAI2
Gene Aliases: SLUG; SLUGH; SLUGH1; SNAI2; SNAIL2; WS2D
UniProt ID: (Human) O43623, (Mouse) P97469
Entrez Gene ID: (Human) 6591, (Mouse) 20583
Molecular Function:
C2H2 zinc finger transcription factor
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