Invitrogen
Catalog # PA5-40072
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
ELISA (ELISA) | 1:100-1:500 |
Western Blot (WB) | 1:500 |
Species reactivity | Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | KLH-conjugated synthetic peptides containing sequences from the central part of the protein corresponding to mouse Setd1b (Set domain containing 1B). |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | Conc. Not Determined |
Storage buffer | whole serum |
Contains | 0.05% sodium azide |
Storage conditions | -20°C or -80°C if preferred |
RRID | AB_2606898 |
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Histone-lysine N-methyltransferase SETD1B; SET domain-containing protein 1B
Gene Aliases: AA516740; BC035291; Kiaa1076; KMT2G; mKIAA1076; Set1b; Setd1b
UniProt ID: (Mouse) Q8CFT2
Entrez Gene ID: (Mouse) 208043
Molecular Function:
histone modifying enzyme
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