Catalog # MA3-925
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 |
Immunoprecipitation (IP) | Assay-dependent |
Western Blot (WB) | 1:5,000 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 98 publications below |
Immunohistochemistry (IHC) | See 15 publications below |
Immunocytochemistry (ICC/IF) | See 23 publications below |
Immunohistochemistry (Paraffin) (IHC (P)) | See 1 publications below |
Immunohistochemistry (Frozen) (IHC (F)) | See 1 publications below |
Miscellaneous PubMed (Misc) | See 1 publications below |
Immunoprecipitation (IP) | See 9 publications below |
Immunohistochemistry - Free Floating (IHC (Free)) | See 1 publications below |
Species reactivity | Amphibian, Bovine, Dog, Chicken, Fish, Human, Mustelid, Mouse, Non-human primate, Sheep, Rabbit, Rat |
Published species | Bovine, Cat, Chicken, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Clone | 34C |
Immunogen | Partially purified chicken pectoral muscle ryanodine receptor. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Protein A |
Storage buffer | PBS |
Contains | 0.05% sodium azide |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_2254138 |
MA3-925 detects ryanodine receptor (RyR)-1 and RyR-2 isoforms in amphibian, chicken, bovine, canine, fish, human, non-human primate, mouse, rabbit, mink, rat and sheep tissues. In chickens this antibody detects the alpha, beta and cardiac isoforms. This antibody also detects RyR-3 in mouse cells. In frog, MA3-925 detects the alpha and beta isoforms and in fish it detects the alpha isoform.
MA3-925 has been successfully used in Western blot, immunohistochemistry, immunofluorescence and immunoprecipitation procedures. By Western blot, this antibody detects a 565 kDa protein representing RyR from rat skeletal muscle extracts. In non-mammalian vertebrates, a doublet is seen at 565 kDa representing the alpha and beta isoforms of the receptor. Immunohistochemical staining of RyR in chicken brain with MA3-925 results in intense staining of cerebellar Purkinje neurons.
The MA3-925 antigen is partially purified chicken pectoral muscle ryanodine receptor.
Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscled cells. Ryanodine receptor, ~500 kDa, can be isolated from a variety of cell types such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscles, cardiac muscle and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: calcium release channel; central core disease of muscle; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like, skeletal muscle; RYR-1; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; type 1-like ryanodine receptor; unnamed protein product
Gene Aliases: AI528790; CCO; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR1; Ryr1l; SKRR
UniProt ID: (Rabbit) P11716, (Human) P21817, (Mouse) E9PZQ0
Entrez Gene ID: (Sheep) 101112591, (Rabbit) 100009540, (Bovine) 100139857, (Human) 6261, (Dog) 606491, (Mouse) 20190, (Rat) 114207
Molecular Function: ligand-gated ion channel scaffold/adaptor protein
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.