Invitrogen
Catalog # PA5-40244
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
ELISA (ELISA) | 1:5,000 |
Immunohistochemistry (IHC) | 1:100-1:300 |
Western Blot (WB) | 1:500-1:2,000 |
Species reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthesized peptide derived from human WNK1 around the phosphorylation site of T60. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
Contains | 0.02% sodium azide |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_2605422 |
This antibody is predicted to react with mouse and rat based on sequence homology.
WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Erythrocyte 65 kDa protein; hWNK1; Kinase deficient protein; MGC163339; MGC163341; p65; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K; WNK lysine deficient protein kinase 1 isoform
Gene Aliases: 6430573H23Rik; EG406236; HSAN2; HSN2; KDP; KIAA0344; mKIAA0344; p65; PPP1R167; PRKWNK1; PSK; WNK1
UniProt ID: (Human) Q9H4A3, (Rat) Q9JIH7, (Mouse) P83741
Entrez Gene ID: (Human) 65125, (Rat) 116477, (Mouse) 232341
Molecular Function: non-receptor serine/threonine protein kinase
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