Catalog # PA1-4628
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:1,000 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 2 publications below |
Species reactivity | Human, Mouse, Rat |
Published species | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser523 of human ALOX5 conjugated to KLH |
Conjugate | Unconjugated |
Form | Liquid |
Purification | Affinity chromatography |
Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
Contains | no preservative |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_2274008 |
This antibody is predicted to react with non-human primate based on 100% sequence homology.
This antibody is specific for the ~80 kDa 5-LO phosphorylated at Ser523 in Western blots of rat hippocampal lysates.
This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5 - Lipoxygenase; 5-lipoxygenase; 5-LO; Arachidonate 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOX-5; lox5; Polyunsaturated fatty acid 5-lipoxygenase; RP11-67C2.3
Gene Aliases: 5-LO; 5-LOX; 5LO; 5LPG; 5LX; AI850497; ALOX5; F730011J02; LOG5; LOX5A
UniProt ID: (Human) P09917, (Rat) P12527, (Mouse) Q3TB75
Entrez Gene ID: (Human) 240, (Rat) 25290, (Mouse) 11689
Molecular Function:
oxygenase
reverse transcriptase
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