TESTED APPLICATIONS | DILUTION |
---|---|
ELISA (ELISA) | Assay-dependent |
Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Immunoprecipitation (IP) | Assay-dependent |
Western Blot (WB) | 1 µg/mL |
Immunocytochemistry (ICC/IF) | 1:500-1:2,000 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 2 publications below |
Published species | Human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Clone | N1404 |
Immunogen | Baculovirus-expressed recombinant human Nurr1 (aa 2-99) |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Storage conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
RRID | AB_2633307 |
MA1-195 detects Nurr1 in human samples, and does not recognize human NGF-B alpha and gamma.
For reducing conditions, Western blot should be performed using an antibody dilution of 1 µg/mL and a dilution of 3 µg/mL for non-reducing conditions.
The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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