Invitrogen
Catalog # PA5-51219
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:30-1:150 |
Species reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Fusion protein of human NPL |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 0.9 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2636667 |
The antibody detects endogenous levels of total NPL protein.
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dihydrodipicolinate synthetase homolog 1; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase
Gene Aliases: C112; C1orf13; NAL; NPL; NPL1
UniProt ID: (Human) Q9BXD5
Entrez Gene ID: (Human) 80896
Molecular Function:
lyase
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.