Invitrogen
This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View details.
Catalog # MA1-91128
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Western Blot (WB) | 1:500 |
Immunocytochemistry (ICC/IF) | 1:500 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 2 publications below |
Immunocytochemistry (ICC/IF) | See 1 publications below |
Immunohistochemistry (IHC) | See 1 publications below |
Species reactivity | Bovine, Dog, Chicken, Cat, Guinea pig, Goat, Hamster, Human, Mouse, Sheep, Pig, Rabbit, Reptile, Rat |
Published species | Horse, Mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Clone | CH-19 |
Immunogen | synthetic peptide DYDYLNDWGPRFKKLADMYGGGDD conjugated to KLH, corresponding to amino acids 889-912 of Chicken N-Cadherin (cdh2). |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 6.1 mg/mL |
Storage buffer | Ascites |
Contains | 15mM sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_1958717 |
Recommended positive controls: MDBK.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1 preproprotein; cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; Cadherin2; calcium-dependent adhesion protein, neuronal; CD325; CDw325; CDw325 antigen; N-cadherin; N-cadherin 1; Neural cadherin; neural calcium-dependent cell adhesion molecule; neural-cadherin; unnamed protein product
Gene Aliases: cadherin-2; CD325; CDH2; CDHN; CDw325; I79_014914; N-cadherin; NCAD
UniProt ID: (Human) P19022, (Chicken) P10288, (Mouse) P15116, (Rat) Q9Z1Y3
Entrez Gene ID: (Sheep) 100170321, (Dog) 480169, (Pig) 100515322, (Goat) 102188004, (Human) 1000, (Bovine) 281062, (Chicken) 414745, (Rabbit) 100344571, (Mouse) 12558, (Chinese hamster) 100689204, (Rat) 83501
Molecular Function:
cadherin
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