Invitrogen
Catalog # PA1-30315
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Flow Cytometry (Flow) | 1:25 |
Immunohistochemistry (Paraffin) (IHC (P)) | 1:10-1:50 |
Western Blot (WB) | 1:1,000 |
Species reactivity | Human, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human DDR1. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Protein A |
Storage buffer | PBS |
Contains | 0.09% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_1957217 |
Detects a band at approximately 100 kDa (predicted molecular weight of 105 kDa). Positive control of placenta lysate suggested.
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD167 antigen-like family member A; CD167a; Cell adhesion kinase; DAAP-278B20.1; DDR1d; discoidin domain receptor family, member 1; Discoidin receptor tyrosine kinase; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; HGK2; Mammary carcinoma kinase 10; MCK-10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase receptor type 4; neurotrophic tyrosine kinase, receptor, type 4; protein-tyrosine kinase 3; Protein-tyrosine kinase 3A; protein-tyrosine kinase PTK-3; Protein-tyrosine kinase RTK-6; PTK3A protein tyrosine kinase 3A; TRK E; Tyrosine kinase DDR; Tyrosine-protein kinase CAK
Gene Aliases: CAK; CD167; DDR; DDR1; Drd1; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; PTK3D; RTK6; TRKE
UniProt ID: (Human) Q08345
Entrez Gene ID: (Human) 780, (Rat) 25678
Molecular Function:
transmembrane signal receptor
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