Catalog # MA1-06104
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Flow Cytometry (Flow) | 1:100-1:200 |
Immunohistochemistry (Frozen) (IHC (F)) | 1:100-1:200 |
Western Blot (WB) | 1:100-1:1,000 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 5 publications below |
Species reactivity | Hamster, Human, Mouse, Pig, Xenopus, Zebrafish |
Published species | Hamster, Human, Mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Clone | LN43 |
Immunogen | Detergent insoluble fraction of potoroo cell line PtK1. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | purified |
Storage buffer | PBS |
Contains | 0.09% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2136415 |
MA1-06104 detects lamin B2 in human, mouse, porcine, Xenopus laevis, zebrafish and hamster samples.
MA1-06104 has sucessfully been used in FACS, immunohistochemistry, and Western blotting procedures.
The MA1-06104 immunogen is a detergent insoluble fraction of potoroo cell line PtK1.
Store at 4ºC, or in small aliquots at -20ºC.
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: lamin B2; lamin B3; Lamin-B2; MGC2721
Gene Aliases: EPM9; fc15d06; im:7142331; LAMB2; lamin; Lamin-B2; Lamin-L(II); LMN2; LMNB2; lmnb2-a; lmnb2-b; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg
UniProt ID: (Human) Q03252, (Mouse) P21619
Entrez Gene ID: (Pig) 100620983, (Human) 84823, (Mouse) 16907, (Chinese hamster) 100766421, (Zebrafish) 30196, (Xenopus) 394291
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