Invitrogen
Catalog # PA1-29899
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
ELISA (ELISA) | 1:10,000-1:100,000 |
Western Blot (WB) | 1-10 µg/mL |
Species reactivity | Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to 17 C-terminal residues of mouse Klotho. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | 0.1M tris HCl, pH 7.5, with 0.2% BSA |
Contains | 0.05% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2249606 |
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HFTC3; Klotho; secreted form of Klotho protein
Gene Aliases: alpha-kl; Kl
UniProt ID: (Mouse) O35082
Entrez Gene ID: (Mouse) 16591
Molecular Function: glycosidase
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