Invitrogen
Catalog # PA5-50692
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:200 |
Western Blot (WB) | 1:500-1:2,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to residues near the N terminal of human potassium large conductance calcium-activated channel, subfamily M, beta member 4 |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 2.9 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2636144 |
The antibody detects endogenous levels of total KCNMB4 protein.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: big potassium channel beta subunit 4; BK channel beta subunit 4; BK channel subunit beta-4; BKbeta4; Calcium-activated potassium channel subunit beta-4; Calcium-activated potassium channel, subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; hbeta4; K(VCA)beta-4; KCMB4; large conductance calcium-dependent potassium ion channel beta 4 subunit; Maxi K channel subunit beta-4; MaxiK channel beta-subunit 4; potassium channel subfamily M regulatory beta subunit 4; potassium large conductance calcium-activated channel, subfamily M, beta member 4; Slo-beta-4; Slowpoke beta 4
Gene Aliases: 1700058G18Rik; 2900045G12Rik; KCNMB4
UniProt ID: (Human) Q86W47, (Mouse) Q9JIN6
Entrez Gene ID: (Human) 27345, (Mouse) 58802
Molecular Function:
voltage-gated ion channel
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