Catalog # PA1-26938
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Frozen) (IHC (F)) | 1:50-1:100 |
Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:100 |
Immunocytochemistry (ICC/IF) | 1:50-1:100 |
PUBLISHED APPLICATIONS | |
---|---|
Immunohistochemistry (IHC) | See 16 publications below |
Flow Cytometry (Flow) | See 2 publications below |
Immunocytochemistry (ICC/IF) | See 4 publications below |
ELISA (ELISA) | See 1 publications below |
Miscellaneous PubMed (Misc) | See 2 publications below |
Functional Assay (FN) | See 1 publications below |
Immunohistochemistry (Paraffin) (IHC (P)) | See 1 publications below |
Species reactivity | Human, Mouse |
Published species | Human, Mouse, Rat |
Host / Isotype | Guinea pig / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Full length human protein. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 0.2 mg/mL |
Storage buffer | PBS/whole serum, pH 7.2, with 0.2% BSA |
Contains | 0.09% sodium azide |
Storage conditions | 4° C, do not freeze |
RRID | AB_794668 |
This antibody stains beta(b) cells of the Langerhan's islets in human pancreas. IHC Note: prolonged fixation in buffered formalin can destroy the epitope.
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ins; Insulin; Insulin-1; Insulin-2; preproinsulin; proinsulin
Gene Aliases: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; Ins2-rs1; InsII; IRDN; Mody; MODY10; Mody4; proinsulin
UniProt ID: (Human) P01308, (Mouse) P01325, (Mouse) P01326
Entrez Gene ID: (Human) 3630, (Mouse) 16333, (Mouse) 16334
Molecular Function: growth factor
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