Invitrogen
Catalog # PA5-49323
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:1,000 |
Species reactivity | Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 0.5 mg/mL |
Purification | Protein A, Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4 |
Contains | 0.09% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2634777 |
Predicted to react with bovine and human based on sequence homology.
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Brgr1; Brgrb; G-protein coupled receptor 68; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Aliases: BB131428; Gpr68; Ogr1
UniProt ID: (Mouse) Q8BFQ3
Entrez Gene ID: (Mouse) 238377
Molecular Function:
G-protein coupled receptor
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