Catalog # PA5-50668
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:200 |
Western Blot (WB) | 1:200-1:1,000 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 1 publications below |
Species reactivity | Human, Mouse, Rat |
Published species | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human glucagon receptor |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 2.7 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2636120 |
The antibody detects endogenous levels of total GCGR / Glucagon Receptor protein.
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GL-R; Glucagon receptor; glucagon receptor perhaps same as Niddm3
Gene Aliases: GCGR; GGR; GL-R; GR
UniProt ID: (Human) P47871, (Mouse) Q61606, (Rat) P30082
Entrez Gene ID: (Human) 2642, (Mouse) 14527, (Rat) 24953
Molecular Function:
transmembrane signal receptor
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