Catalog # PA1-46151
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Frozen) (IHC (F)) | 1:200 |
Immunohistochemistry (Paraffin) (IHC (P)) | 1:100-1:500 |
Western Blot (WB) | 1:500-1:1,000 |
Immunocytochemistry (ICC/IF) | 1:100-1:500 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 1 publications below |
Immunohistochemistry (IHC) | See 1 publications below |
Species reactivity | Chicken, Human, Mouse, Rat |
Published species | Guinea pig |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide comprising residues 1159-1171 of the human GluR1 protein. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS |
Contains | 0.02% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_1017267 |
Suggested positive control: human brain lysate, rat dorsal root ganglion, and rat brain (cingulate cortex), antigen standard for GRIN1 (transient overexpression lysate).
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate receptor; glutamate receptor, metabotropic 1; GRM1A; Metabotropic glutamate receptor 1; mGluR1; mGluR1a; protein phosphatase 1, regulatory subunit 85
Gene Aliases: 4930455H15Rik; ENSMUSG00000075319; Gm10828; GPRC1A; GRM1; MGLU1; MGLUR1; nmf373; PPP1R85; rcw; SCAR13; wobl
UniProt ID: (Human) Q13255, (Mouse) P97772, (Rat) P23385
Entrez Gene ID: (Human) 2911, (Chicken) 421614, (Mouse) 14816, (Rat) 24414
Molecular Function:
G-protein coupled receptor
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