Invitrogen
Catalog # PA5-49829
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:500-1:3,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthesized peptide derived from internal of human SPR1. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 50% glycerol |
Contains | 0.02% sodium azide |
Storage conditions | -20°C |
RRID | AB_2635282 |
The antibody detects endogenous levels of total GPR68 protein.
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It represents an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulate inositol phosphate (IP) production or CA2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also found to serve as a tumor suppressor in prostate cancer. Mutations to the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Brgr1; Brgrb; G-protein coupled receptor 68; GPR12A; OGR-1; ovarian cancer G protein-coupled receptor, 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor
Gene Aliases: BB131428; GPR12A; GPR68; OGR1
UniProt ID: (Human) Q15743, (Mouse) Q8BFQ3
Entrez Gene ID: (Human) 8111, (Mouse) 238377
Molecular Function: G-protein coupled receptor
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