Catalog # PA5-50973
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
ELISA (ELISA) | 1:5,000 |
Western Blot (WB) | 1:500-1:2,000 |
Immunocytochemistry (ICC/IF) | 1:200-1:1,000 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 1 publications below |
Immunocytochemistry (ICC/IF) | See 1 publications below |
Species reactivity | Human, Mouse, Rat |
Published species | Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthesized peptide derived from the Internal region of human GPR120. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
Contains | 0.02% sodium azide |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_2636421 |
GPR120 Polyclonal Antibody detects endogenous levels of GPR120 protein.
An EST for GPR120 has been isolated from a human colon cancer library. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Free fatty acid receptor 4; G protein-coupled receptor 120; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; G-protein-coupled receptor GT01; GPCR120; Omega-3 fatty acid receptor 1
Gene Aliases: AI552415; BMIQ10; FFAR4; GPR120; GPR129; GT01; KPG_013; O3FAR1; PGR4
UniProt ID: (Human) Q5NUL3, (Mouse) Q7TMA4, (Rat) Q2AC31
Entrez Gene ID: (Human) 338557, (Mouse) 107221, (Rat) 294075
Molecular Function:
G-protein coupled receptor
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