Invitrogen
Catalog # PA5-50611
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:200-1:1,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to residues near the C terminal of human gastric inhibitory polypeptide receptor |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1.1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2636064 |
The antibody detects endogenous levels of total GIPR / GIP Receptor protein.
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Gene Aliases: GIP-R; GIPR; Gm1081; Gm160; PGQTL2
UniProt ID: (Human) P48546, (Mouse) Q0P543
Entrez Gene ID: (Human) 2696, (Mouse) 381853
Molecular Function:
transmembrane signal receptor
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