Invitrogen
Catalog # OPA1-04114
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:1,000 |
Species reactivity | Mouse, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to amino acid residues specific to the alpha 6 subunit of rat GABRA6 conjugated to KLH |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | Conc. Not Determined |
Storage buffer | whole serum |
Contains | no preservative |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_325091 |
In Western blot, this antibody detects a ~57 kDa protein representing GABA-A R alpha 6 subunit in rat brain lysate. The immunogenic sequence has no homology with any other GABA-A receptor subunits.
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GABA(A) receptor subunit alpha-6; GABA-A receptor alpha-6 subunit; GABAAR alpha6; GABRA 6; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
Gene Aliases: alpha6; GABA-ARalpha6; Gabra-6; Gabra6
UniProt ID: (Mouse) P16305, (Rat) P30191
Entrez Gene ID: (Mouse) 14399, (Rat) 29708
Molecular Function:
ligand-gated ion channel
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