Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View details.
Catalog # PA1-4146
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:500 |
Species reactivity | Human, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to residues T(42) R G A P R P P P S S P P(54) of the 105 kDa rat GABA R2 protein. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS |
Contains | 0.02% sodium azide |
Storage conditions | -20° C, Avoid Freeze/Thaw Cycles |
RRID | AB_2108023 |
PA1-4146 detects GABA Receptor Associated Protein Subunit 2 in human and rat samples.
PA1-4146 has been successfully used Western blot procedures. By Western blot this antibody detects a ~105 kDa protein representing GABA Receptor Associated Protein Subunit 2 in brain lysate.
The PA1-4146 immunogen is a synthetic peptide corresponding to residues T(42) R G A P R P P P S S P P(54) of the 105 kDa rat GABA R2 protein.
Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ25768; GABA(A) receptor-associated protein; GABARAP a; gamma-aminobutyric acid receptor associated protein; Gamma-aminobutyric acid receptor-associated protein; hypothetical protein; MGC120154; MGC120155; MM46
Gene Aliases: ATG8A; FLC3B; GABARAP; GABARAP-a; HT004; MM46
UniProt ID: (Human) O95166, (Rat) P60517
Entrez Gene ID: (Human) 11337, (Rat) 58974
Molecular Function:
non-motor microtubule binding protein
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