Catalog # PA1-24685
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunoprecipitation (IP) | 10-20 µg/mL |
Western Blot (WB) | 1:1,000 |
Immunocytochemistry (ICC/IF) | 1:100 |
PUBLISHED APPLICATIONS | |
---|---|
Western Blot (WB) | See 1 publications below |
Species reactivity | Human, Mouse, Rat |
Published species | Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide, conjugated to KLH, corresponding to residues 487-505 of human FRS2alpha. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1.9 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | 0.01M PBS, pH 7.4, with 1% BSA |
Contains | 15mM sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2247174 |
PA1-24685 detects a band of ~92 and 95 kDa. Positive control of rat PC-12 and human HepG2 cell lysates suggested.
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2-alpha; SNT-1; SNT2; Suc1-associated neurotrophic factor target 1
Gene Aliases: 4732458E18; C330018A15Rik; FRS1A; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
UniProt ID: (Human) Q8WU20, (Mouse) Q8C180
Entrez Gene ID: (Human) 10818, (Mouse) 327826, (Rat) 314850
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