Invitrogen
Catalog # PA1-4168
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:500-1:1,000 |
Species reactivity | Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to residues W(1909) T R N D D R E I L L E(1920) of mouse FLASH. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS |
Contains | 0.02% sodium azide |
Storage conditions | Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID | AB_2068767 |
PA1-4168 detects the FLASH protein in mouse samples.
PA1-4168 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~212 kDa protein representing FLASH in NIH3T3 cells.
The PA1-4168 immunogen is a synthetic peptide corresponding to residues W(1909) T R N D D R E I L L E(1920) of mouse FLASH.
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CASP8-associated protein 2; casp8ap2; FLICE-associated huge protein; FLJ11208; RP11-63K6.3
Gene Aliases: AA387232; Casp8ap2; D4Ertd659e; FLASH; mKIAA1315
UniProt ID: (Mouse) Q9WUF3
Entrez Gene ID: (Mouse) 26885
Molecular Function:
protein-binding activity modulator
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