Invitrogen
Catalog # PA5-49138
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:1,000 |
Species reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | KLH conjugated synthetic peptide between 12-38 amino acids from the N-terminal region of human EXOSC6. |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 0.5 mg/mL |
Purification | Protein A, Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4 |
Contains | 0.09% sodium azide |
Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID | AB_2634594 |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Exosome complex component MTR3; exosome complex exonuclease MTR3; Exosome component 6; hMtr3; homolog of yeast mRNA transport regulator 3; mRNA transport regulator 3 homolog; Mtr3 (mRNA transport regulator 3)-homolog; p11
Gene Aliases: EAP4; EXOSC6; hMtr3p; MTR3; Mtr3p; p11
UniProt ID: (Human) Q5RKV6
Entrez Gene ID: (Human) 118460
Molecular Function:
exoribonuclease
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