Invitrogen
Catalog # PA5-51313
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:100-1:200 |
Western Blot (WB) | 1:500-1:2,000 |
Species reactivity | Human, Rat |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Full length fusion protein of human CCBL1 |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1.2 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2636760 |
The antibody detects endogenous levels of total CCBL1 protein.
Kynurenine aminotransferases KAT I, KAT II, and KAT III belong to the class-I pyridoxal-phosphate-dependent aminotransferase family. KAT I is a cytoplasmic protein involved in glutamine catabolism. KAT I functions in the catalysis of the transamination of L-kinurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan. Kynurenic acid is involved in synaptic transmission and has been implicated in a number of neurological disorders including schizophrenia and Huntington's disease. KAT I also functions in the metabolism of cysteine conjugates in some halogenated alkenes and alkanes to form reactive metabolites. KAT I has three isoforms. Isoform 1is the full length protein, isoform 2 lacks amino acids 68-117 and isoform 3 lacks amino acids 251-422. Based on sequence similarity, KAT I is thought to function as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: beta-lysase, kidney; cysteine conjugate beta lyase 1; cysteine conjugate-beta lyase 1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; glutamine-phenylpyruvate aminotransferase; GTK; KATI; kyneurenine aminotransferase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; kynurenine aminotransferase/glutamine transaminase K; Kynurenine--oxoglutarate transaminase 1; kynurenine--oxoglutarate transaminase 1, mitochondrial; Kynurenine--oxoglutarate transaminase I
Gene Aliases: CCBL1; GTK; Kat; KAT1; KATI; KYAT1
UniProt ID: (Rat) Q08415, (Human) Q16773
Entrez Gene ID: (Rat) 311844, (Human) 883
Molecular Function:
transaminase
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