Invitrogen
Catalog # PA5-50603
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Western Blot (WB) | 1:200-1:1,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human AT rich interactive domain 1A (SWI-like) |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 2.4 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2636056 |
The antibody detects endogenous levels of total ARID1A protein.
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARID domain-containing protein 1A; AT rich interactive domain 1A (SWI-like); AT rich interactive domain 1A (Swi1 like); AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; chromatin remodeling factor p250; h BM029; hELD; hOSA1; Osa homolog 1; OSA1 nuclear protein; SWI-like protein; SWI-SNF complex protein p270; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; Swi1 like
Gene Aliases: 1110030E03Rik; ARID1A; B120; BAF250; BAF250A; BM029; C1orf4; CSS2; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
UniProt ID: (Human) O14497, (Mouse) A2BH40
Entrez Gene ID: (Human) 8289, (Mouse) 93760
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