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Invitrogen

AMID Polyclonal Antibody

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Catalog # PA1-4345

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Product Details

TESTED APPLICATIONS DILUTION
Western Blot (WB) 1:500
Species reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Synthetic peptide: V(170) T L I H S Q V A L A D K E L L(185)
Conjugate Unconjugated
Form Liquid
Concentration 1 mg/mL
Purification Antigen affinity chromatography
Storage buffer PBS
Contains 0.02% sodium azide
Storage conditions -20° C, Avoid Freeze/Thaw Cycles
RRID AB_2169232

Product Specific Information

PA1-4345 detects the human PRG3 protein in human samples.

PA1-4345 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~41 kDa protein representing PRG3 in human heart lysate.

The PA1-4345 immunizing peptide corresponds to amino acid residues residues 170-185 of the 41 kDa human PRG3 protein.

Background/Target Information

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AMID; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated, 2; Ferroptosis suppressor protein 1; FSP1; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; RP11-367H5.2

Gene Aliases: AIFM2; AMID; PRG3

UniProt ID: (Human) Q9BRQ8

Entrez Gene ID: (Human) 84883

Molecular Function: Blue Arrow Icon oxidoreductase Blue Arrow Icon metabolite interconversion enzyme

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If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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