Invitrogen
Catalog # PA5-50315
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:25-1:100 |
Western Blot (WB) | 1:500-1:2,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Fusion protein corresponding to a region derived from internal residues of human aldehyde dehydrogenase 8 family, member A1 |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1.1 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2635768 |
The antibody detects endogenous levels of total ALDH8A1 protein.
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; aldehyde dehydrogenase 8 family, member A1; Aldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase family protein; Retinal dehydrogenase 4; retinal dehydrogenase type 4
Gene Aliases: ALDH12; ALDH8A1; DJ352A20.2; Raldh4
UniProt ID: (Human) Q9H2A2, (Mouse) Q8BH00
Entrez Gene ID: (Human) 64577, (Mouse) 237320
Molecular Function:
dehydrogenase
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