Invitrogen
Catalog # PA5-50195
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:200 |
Western Blot (WB) | 1:500-1:2,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Fusion protein corresponding to a region derived from internal residues of human Alanyl-tRNA synthetase 2, mitochondrial |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1.3 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2635648 |
The antibody detects endogenous levels of total AARS2 protein.
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AARS2; alanine tRNA ligase 2, mitochondrial (putative); Alanine--tRNA ligase, mitochondrial; Alanyl-tRNA synthetase; alanyl-tRNA synthetase 2, mitochondrial (putative); alanyl-tRNA synthetase like; alanyl-tRNA synthetase, mitochondrial; AlaRS; bA444E17.1; probable alanyl-tRNA synthetase, mitochondrial
Gene Aliases: AARS2; AARSL; AlaRS; COXPD8; Gm89; KIAA1270; LKENP; MT-ALARS; MTALARS
UniProt ID: (Human) Q5JTZ9, (Mouse) Q14CH7
Entrez Gene ID: (Human) 57505, (Mouse) 224805
Molecular Function:
aminoacyl-tRNA synthetase
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