The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B, and the amino-terminal (residues 45-170) contains a cysteine-rich rich region with two zinc finger motifs. Rabphilin-3A belongs to a family of other carboxyterminal type (C-type) tandem C2 proteins, which includes synaptotagmins and Doc2. Rabphilin is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules. Rabphilin-3A binds Rab3a/GTP/Mg+ within amino-terminal residues 45 and 170. Rabphilin-3A binds calcium ions and phosphatidylinositol 4,5-bisphophate containing lipid vesicles within its C2 domains. Rabphilin-3A is a positive regulator of calcium dependent exocytosis, while Rab3a is a negative regulator of exocytosis. Although rabphilin-3A associates with Rab3a, they seem to influence exocytosis independently of each other. Rabphilin-3A effects are likely mediated through interactions with an unknown factor that recognizes the Rab3 binding domain.
Invitrogen
RPH3A Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™ RPH3A Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™Cat # PA1774
100 µg
Proteintech
RPH3A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech RPH3A Rabbit anti-Human, Mouse, Rat, Polyclonal, ProteintechCat # 50-172-7122
150 µL
Invitrogen
RPH3A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™ RPH3A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™Cat # PIPA575192
100 µL
Abnova
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100 uL
Invitrogen
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100 µL
Invitrogen
RPH3A Rabbit anti-Rat, Polyclonal, Invitrogen™ RPH3A Rabbit anti-Rat, Polyclonal, Invitrogen™Cat # APP4692
100 µL
Abnova
RPH3A Rabbit anti-Human, Polyclonal Antibody, Abnova™ RPH3A Rabbit anti-Human, Polyclonal Antibody, Abnova™Cat # 89-121-621
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Abnova
RPH3A Rabbit anti-Bovine, Dog, Human, Mouse, Primates, Rat, Polyclonal Antibody, Abnova™ RPH3A Rabbit anti-Bovine, Dog, Human, Mouse, Primates, Rat, Polyclonal Antibody, Abnova™Cat # 89-134-288
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Invitrogen
RPH3A Rabbit anti-Mouse, Polyclonal, Invitrogen™ RPH3A Rabbit anti-Mouse, Polyclonal, Invitrogen™Cat # PIPA535960
100 µL
Invitrogen
RPH3A Rabbit anti-Human, Polyclonal, Invitrogen™ RPH3A Rabbit anti-Human, Polyclonal, Invitrogen™Cat # PIPA551713
100 µL
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