3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.
Invitrogen
3-Methylcytosine Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™ 3-Methylcytosine Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™Cat # PA540098
50 µg
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