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Thermo Scientific™ Octylthioglucoside (OTG) Detergent

Lyse cells and solubilize proteins without denaturing them using this low-MW nonionic detergent that is resistant to beta-D-glucoside digestion (unlike Octyl-beta-glucoside).

Supplier:  Thermo Scientific™ 28351

Catalog No. PI28351

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Perform effective cell lysis and nondenaturing protein solubilization with Thermo Scientific™ Octylthioglucoside (OTG), a low-MW nonionic detergent.


  • A low-molecular weight, nonionic detergent
  • Effective for a variety of cell lysis and protein solubilization methods
  • Unaffected by beta-glucosidase enzyme
  • More stable than octyl beta-glucoside (OG)
  • Can be removed from solution by dialysis
  • Optically clear; low absorbance at 280nm

Detergent Properties:

  • Alternative Names: Octylthioglucoside, OTG
  • Chemical Name: n-Octyl β-D-thioglucopyranoside
  • Molecular Weight: 308.44
  • Detergent Class: Nonionic
  • Aggregation Number: Unknown
  • Micelle Molecular Weight: Unknown
  • Critical Micelle Concentration (CMC): 9mM (0.2772%, w/v)
  • Cloud Point: > 100°C
  • Dialyzable: Yes


5 g
Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, between the following temperatures: 2 to 8°C.
Detergent (Pure)


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